摘要
防腐剂是多剂量水性介质鼻用制剂不可或缺的组成部分。近年来人们发现防腐剂可能会对呼吸道黏膜功能产生不良影响,体外实验几乎一致表明防腐剂如苯扎氯铵可产生局部不良反应,但体内结果差异较大,造成矛盾的原因与体内外环境差异及试验方法有关。尽管如此,防腐剂带来的不良影响已经引起人们的关注,努力寻求毒性更低的防腐剂或不含防腐剂的装置是鼻腔给药系统发展的方向之一。
出处
《国际耳鼻咽喉头颈外科杂志》
2009年第4期242-246,共5页
International Journal of Otolaryngology-Head and Neck Surgery
基金
973前期资助项目(2007CB516706)
国家自然科学基金资助项目(30572026)
参考文献23
-
1郑俊民.药用辅料手册.北京:化学工业出版社,2005:53-55.
-
2Deutschle T,Porkert U,Reiter R,et al.In vitro genotoxicity and cytocoxicity of benzalkonium chloride.Toxicology in Vitro,2006,20(8):1472-1477.
-
3Mallants R,Jorissen M,Augustijns P.Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture:single versus multiple exposure.Int J Pharm.,2007,338(1-2):64-69.
-
4Morimoto K,Uehara Y,Iwanaga K,et al.Influence of absorption enhancers (bile salts) and the preservative (benzalkonium chloride) on mucociliary function and permeation barrier function in rabbit tracheas.Eur J Pharm Sci,1998,6(3):225-230.
-
5Hofmann T,Gugatschga M,Koidl B,et al.Influence of Preservatives and Topical Steroids on Ciliary Beat Frequency In Vitro.Arch Otolaryngol Head Neck Surg,2004,130(4):440-445.
-
6Cho JH,Kwun YS,Jang HS,et al.Long-term use of preservatives on rat nasal respiratory mucosa:citects of benzalkonium chloride and potassium sorbate.Laryngoscope,2000,110(2 Pt 1):312-317.
-
7Berg OH,Lie K,Steinsvhg SK.The effects of topical nasal stcroids on rat respiratory mucosa in vivo with special reference to the preservative benzalkoninm chloride.Allergy,1997,52(6):627-632.
-
8Graf P.Adverse Efiects of Benzalkonium Chloride on the Nasal Mucosa:Allergic Rhinitis and Rhinitis Medicamentosa.Ciln Ther,1999,21(10):1749-1755.
-
9Graf P.Hallen H.Effect on the nasal mucosa of long-term treatment with oxymetazoline,benzalkonium chloride,and placebo nasal sprays.Laryngoscope,1996,106(5 Pt 1):605-609.
-
10Ainge G.Bowles JAK,McCormick SG,et al.Lack of deleterious effects of corticosteroid sprays containing bcnzalkoniurn chloride on nasal ciliated epithelium:in vivo results in laboratory animals.Drug Invest,1994,8(2):127-133.
同被引文献17
-
1罗晶,施法,陈晓辉,侯峰,冯影.HPLC法同时测定抗病毒口服液中4种防腐剂[J].西北药学杂志,2012,27(1):36-38. 被引量:14
-
2李秀婷.糖浆剂、合剂中防腐剂测定[J].中国药业,2005,14(10):45-46. 被引量:4
-
3国家药典委员会.中华人民共和国药典(一部).附录Ⅱ,2010:9.
-
4潘学田.中国医院制剂规范·西药制剂.第2版.北京:中国医药科技出版社,1995:4.
-
5British Pharmacopoeia Commision. British Pharmacopeia. 2013: 144-145.
-
6British Pharmacopoeia Commision. USP ED36. Volume 1, 2012(79): 684-686.
-
7European pirectorate for the quality of medicines European Pharmacopeia, 2013:528-529.
-
8国家质量监督检验疫总局.食品中山梨酸、苯甲酸的测定.GB/T5009.29-2003.
-
9陈英,余国中.盐酸赛洛唑啉中杂质A及其他有关物质测定方法的建立[J].药物分析杂志,2010,30(1):142-144. 被引量:4
-
10安彦.眼用制剂中抑菌剂的应用与质量控制[J].天津药学,2011,23(1):56-58. 被引量:23
引证文献2
-
1陈媛,丘增萍,吴楣,蓝红梅,宋增炫,陈文露.高效液相色谱法测定合剂中苯甲酸的含量[J].中国现代药物应用,2014,8(11):1-3. 被引量:1
-
2黄金秋,梁琴,李苗.HPLC法同时测定盐酸赛洛唑啉鼻用喷雾剂主药和抑菌剂含量、递送剂量均一性及有关物质[J].药物分析杂志,2023,43(8):1394-1401. 被引量:2
二级引证文献3
-
1吴宁宁,高运通.高效液相色谱法测定食品中脱氢乙酸含量的方法优化[J].产业与科技论坛,2019,18(11):68-69. 被引量:3
-
2章娟,丁怡,石颖.基于国家药品抽检的布洛芬混悬液中抑菌剂含量测定及评价[J].沈阳药科大学学报,2023,40(12):1608-1613. 被引量:2
-
3王跃,尹燕杰.鼻用冷敷凝胶(露)中盐酸萘甲唑啉、盐酸苯海拉明及盐酸利多卡因补充检验方法研究[J].药物分析杂志,2024,44(9):1624-1631.
-
1鲍春红,黑静,黄峰,王丽.保护早产儿胃肠道黏膜功能的研究进展[J].临床和实验医学杂志,2008,7(1):154-155. 被引量:6
-
2黄雪琨,李源.慢性鼻腔及鼻窦炎黏膜中的黏蛋白[J].国际耳鼻咽喉头颈外科杂志,2007,31(2):65-67.
-
3何力,孙淑英.含有微晶纤维素——海藻酸盐的混悬液[J].辽宁医药,2001,16(1):35-35.
-
4张奕,蒋新国,姚洁.Lowering of sodium deoxycholate-induced nasal ciliotoxicity with cyclodextrins[J].Acta Pharmacologica Sinica,2001,22(11):1045-1050. 被引量:3
-
5Developing and applying of SAN-E reagent red blood cell preservatives olution[J].中国输血杂志,2001,14(S1).
-
6黄世杰.舒马曲坦鼻吸粉获FDA批准用于治疗偏头痛[J].国际药学研究杂志,2016,43(3):480-480. 被引量:1
-
7Prabin Gyawali,Madhurima Mukherjee,Rajesh Kumar Thakur,Krishnananda Prabhu,Anjali Rao.Can glucose preservatives be avoided in blood samples?[J].海南医学院学报,2009,15(12):1520-1523.
-
8XU Chun Di 1, GAN Ren Bao 2, CHEN Shun Nian 1, JIANG Shi Hu 1 and XU Jia Yu 1.Protection of gastric mucosa from ethanol induced injury by recombinant epidermal growth factor in rats[J].World Journal of Gastroenterology,1998,4(5):74-75. 被引量:6
-
9Archimedes的新型药物输送技术有进展[J].国外药讯,2009(5):27-27.
-
10张志芬.从《中国药典》2005年版附录看中药鼻用制剂的研究进展[J].中草药,2005,36(12):1913-1913. 被引量:2