高渗盐/甘露醇液对失血性休克兔心肌收缩能力和血压的影响

The effects of hypertonic saline/mannitol resuscitation onthe myocardiac contractility and blood pressure of rabbitswith hemorrhagic shock

应用家兔失血性休克模型，观察高渗氯化钠／甘露醇液（ＨＳＭ）、高渗醋酸钠／甘露醇液（ＨＡＭ）、高渗氯化钠／右旋糖酐液（ＨＳＤ）对其心肌收缩能力，动脉血压的影响。结果表明：三组高渗胶液仅小剂量能在很短时间内升高休克兔的左室内压、左室内压变化速率及动脉血压。ＨＳＭ对上述指标的影响较ＨＳＤ，ＨＡＭ更大（Ｐ＜０．０５），血压升高的时间与心肌收缩能力变化的时间同步，对高渗高胶液抗休克的机制进行了探讨。

Eighteen healthy adult male rabbits were hemorraged to shock and treated with hypertonichyperoncotic solutions in 3 groups (6 per group): hypertonic saline/dextran(HSD), hypertonic saline/mannitol(HSM) and hypertonic acetate/mannitol(HAM). The results showed that HSM, HAM and HSD could raise the left ventricular pressure(LVP), maxium change rate of LVP (±dp/dt max) and the arterial blood pressure of hemorrhagic shock rabbits quickly at small dose. The efficiency of HSM was better than that of HSD and HAM (P<0.05), and the time of blood pressure rise was in accordance with that of LVP and ±dp/dt max, which may partly explain the mechanism of shock resuscitation by hypertonichyperoncotic solution.