五子衍宗丸和金匮肾气丸对动物生精功能影响的比较研究

Comparative Study on the Effects of Wuziyanzong Pills and Jinkuishenqi Pills on Spermatogenesis Function

目的:研究五子衍宗和金匮肾气两种经典补肾中药的作用机理。方法:利用白消安小鼠无精子症动物模型,给予两种中药单一和联合灌胃给药78天(2个生精周期),以造模后自然恢复、二甲基亚砜溶媒和正常动物为3种对照。结果:两种中药对睾丸生精能力影响的明显不同表现为,五子衍宗主要作用于睾丸的生精上皮细胞,金匮肾气主要作用于睾丸的间质细胞。结论:两种经典补肾中药均具有较强的、明确的促进生精功能恢复的作用。

Objective： To investigate the reinforcing kidney mechanisms of Wuziyanzong pills and Jinkuishenqi pills. Methods： Azoospermia mice caused by busulfan were selected as animal models. Wuziyanzong pills and Jinkuishenqi pills were treated by intragastric administration for 78 days （2 spermatogenesis cycles） and compared respectively with the three control groups of mice with spontaneous recovery, mice treated with DMSO（solvent control） and normal mice. Results： The effects of the two pills on spermatogenesis function were significantly different. Wuziyanzong pills mainly affected on spermatogenic epithelium of testis, and Jinkuishenqi pills mainly affected on testicular interstitial ceils. Conclusion： The two classic Chinese herbs have corroborative and stronger effects on spermatogenesis functional recovery.