急性脑损伤后继发性脑肿胀和脑水肿发生机制的实验研究

Experimental Study on Physiopathological Mechanism of Secondary Brain Swelling and Brain Edema Following Acute Brain Injury

目的研究脑损伤后脑继发性损害中，脑肿胀和脑水肿的病理改变，探讨其相互关系。方法通过脑损伤动物模型，按时间顺序分成４个时相观察组（即６、２４、７２小时和７天），在光镜和电镜下观察脑损伤后不同时相的病理变化，同时测定脑含水量。结果发现脑肿胀在伤后６小时已出现、２４小时达高峰、以后逐渐下降，而脑水肿在伤后２４小时明显、７２小时达高峰、１周后开始下降。结论脑损伤后脑继发性损害是先出现脑肿胀而后出现脑水肿，而并非只出现脑水肿一种病理状态。

Aim To study the pathological changes of and relationship between secondary brain swelling and brain edema following acute brain injury. Methods The pathological changes at different time points (6,24,72 hour and 7 day) and the brain water content were measured under the light and electric microscope on the model of brain injury of Guinea pig and tested at every time phase. Results Brain swelling appeared at 6 hour after brain injury, and reached peak at 24 hour then decreased gradually. Brain edema appeared obviously at 24 hour after brain injury, reached peak at 72 hour and one week later it gradually dropped. Conclusion Brain swelling appears earlier than brain edema after brain injury, and they can coexist.