摘要
为探讨大剂量激素对脑创伤后脑微循环及血液流变性的影响，将２４只家兔随机等分为３组：标准对照组、损伤对照组和地塞米松治疗组。分别在伤前０．５ｈ、伤后０．５ｈ、１ｈ、２ｈ、３ｈ测量软脑膜微动脉管径和血流速度的变化及伤后３ｈ血液流变学指标。结果表明：大剂量激素在伤后０．５ｈ就能明显地扩张损伤处软脑膜的微动脉并使血流速度明显加快。伤后３ｈ能明显降低血沉、全血粘度、红细胞压积及纤维蛋白原含量，并明显增强红细胞的变形能力，降低其聚集性。
To understand the effects of high-dose dexamethasone on pia mater microcirculation and hemorheology,24 rabbits were randomly divided into 3 groups:standard group, the trauma group and the dexamethasone treatment group.Parameters about pia mater microcirculation and hemorheology were measured at different interval.The results showed that high-dose dexamethasone had significant role of extending pia mater microartery,increasing pia mater blood flow-rate,reducing whole blood viscosity,erythrocyte aggregation,ESR,HCT,and increasing erythrocyte deformability.The results suggest that high-dose dexamethasone can improve cerebral microcirculation and hemorheology in rabbits with cerebral trauma.
出处
《微循环学杂志》
1998年第2期10-12,共3页
Chinese Journal of Microcirculation
关键词
激素
脑创伤
血液流变学
微循环
Dexamethasone
Trauma, brain
Microcirculation
Hemorheology
