生物降解材料聚乳酸-聚乙二醇的合成及表征

Synthesis of Polylactic Acid-Polyethylene Glycol via Melt Copolymerization

采用熔融共聚法合成聚乳酸-聚乙二醇,探讨了催化剂种类及其用量、反应温度、反应时间、聚乙二醇的种类及其用量对产物分子量的影响,并对产物进行了表征。实验结果表明,170℃,0.8%辛酸亚锡催化作用下,乳酸与1%PEG400共聚10h可合成黏均分子量为2.79×104的PLA-PEG共聚物,且亲水性有较大改善。

In this study, Polylactic Acid-Polyethylene glycol （PLAPEG） was synthesized via melt copolymerization. The influence of the type and the amount of catalyst, the reaction temperature, the reaction time, the type and the amount of PEG on molecular weights of products are discussed. The performances of products are analyzed. The results show that from lactic acid and 1% polyethylene glycol （PEG） [Mn =400] with 0.8% stannous tin as catalyst, under the condition of 170℃, for 10 h, one obtains Polylactic Acid-Polyethylene glycol （Mη=2.79×10^4）, with improved hydrophilicity.