肌痛、肌无力、肌萎缩与血管炎(附79例报告)

The relationship about vasculitis with myoalgia, myoasthenia and myoatrophy (report of 79 cases ).

目的探讨血管炎与肌痛、肌无力、肌萎缩的关系。方法观察了７９例表现为肌痛、肌无力、肌萎缩，经病理证实为血管炎之患者的临床、有关实验室检查、肌电图及肌肉神经病理活检情况。结果血管炎可仅累及周围神经、肌肉而无其它器官及系统损害；其免疫学指标有异常改变；肌电图可表现为肌病性改变和／或周围神经性改变；腓肠神经、肌肉活检可见束周肌纤维萎缩，少量炎性细胞浸润；神经原性损害者可见神经髓鞘或轴索的病理改变以及肌肉的小群组化、角形纤维、靶纤维等改变。结论血管炎是肌痛、肌无力。

Objective The aim of the study was to investigate the relationship about vasculiis with myoalgia , myoasthenia and myoatrophy. Methods The clinical feature, laboratory examinations, electromyograms and myoneural pathologic biopsies were studied in seventy-nine patients with myoalgia, myoasthenia, myoatrophy and systematic vasculitis. Results It was shown that systematic vasculitis can produce the myoneural damages. The immunological examination of the patient is abnormal, and the electromyogram indicated myopathic and/or perineural changes. Besides the vasculitis changes, perifascicular atrophy and a mononuclear phagocytosed cells infiltrating in myopathic damage, as well as the changes of neural myelin or axon, small type grouping, cornifiber and target fiber in neural lesion were observed. Conclusions It was suggested that vasculaitis is one of the main pathogenetic reason inducing myoalgia, myoasthenia and myoatrophy.