钛酸酯偶联剂对磷灰石/壳聚糖多孔生物材料性能的影响

Influence of Titanate Coupling Agent on Properties of Apatite/Chitosan Porous Biomaterials

以螯合型焦磷酸钛酸酯偶联剂(NDZ-311)为改性剂对壳聚糖(CS)进行改性,采用真空冷冻干燥法制备了HA-TCP/CS多孔生物材料,研究了NDZ-311的用量与多孔生物材料抗压强度和孔隙率的关系,并采用SEM、XRD、IR等对材料进行了分析测试。结果表明,NDZ-311中-O-链状醚键官能团能发生各种类型的酯基转化反应,与CS填料产生交联,材料的抗压强度得到提高,CS填料添加量可达50%以上,且不会发生相分离。随着NDZ-311含量的增加,多孔生物材料的抗压强度先逐渐降低然后升高,孔隙率先逐渐升高然后降低。当m(HA-TCP)∶m(CS)=7∶3时,NDZ-311质量分数为1%时抗压强度为2.3MPa,孔隙率升至最高84.8%,此时多孔生物材料的抗压强度和孔隙率匹配较好,孔隙呈层错板条搭接,且分布均匀,HA-TCP颗粒均匀分散在CS模板上,材料的相结构变化不大,只是材料中各相对应的特征衍射峰的强度略有增强。

Chelate pyrophosphate titanate coupling agent（NDZ-311） is used as modified agent to modify chitosan（CS）. Porous HA-TCP/CS biomaterials are prepared by vacuum freeze drying method. Influence of the amount of coupling agent NDZ-311 on the relationship between compressive strength and porosity of the porous biomaterials is investigated. Analyses of the composite materials are carried out by means of SEM, XRD and IR. The results show that the -O- catenarian aether bond function group in NDZ-311 can induce many types of ester-based transformation reactions to make NDZ-311 and CS filler crosslinking, therefore, the compressive strength of porous biomaterials can be improved by adding NDZ-311 to CS. The addition of CS filler can be more than 50% and can not be separated from phase. Compressive strength of the porous biomaterials decreases with the increase of the content of NDZ-311, and then increases with further increase of the content of NDZ-311. Porosity of the porous biomaterials increases with the increase of the content of NDZ-311, and then decreases with further increase of the content of NDZ-311. Matching of compressive strength and porosity of the porous biomaterials is the best with the mass ratio of HA-TCP to CS 7 ： 3, the content of NDZ-311 is 1wt% when compressive strength and porosity of the porous biomaterials are 2. 3MPa and 84. 8 %, respectively. Pore shape is stacking fault lath lapping and distribution of pore was comparative uniform. HA- TCP particles are uniformly dispersed on CS templates. The added coupling agent of NDZ-311 has little change on the phase structure of the materials, only the intensity of characteristic diffraction peaks in each phase of the materials has a little enhancement.