阿托伐他汀、多西环素改善劳力性心绞痛病人运动耐量的效果研究

目的比较阿托伐他汀与多西环素对心绞痛病人临床疗效及对运动耐量的影响。方法选择60例冠心病稳定型心绞痛伴血脂正常病人,随机分为2组,分别予阿托伐他汀10mg,po,qn×8wk及多西环素100mg,po,qd×8wk,比较每周心绞痛发作次数及硝酸甘油消耗量,运动耐量及血脂水平。结果阿托伐他汀及多西环素均能减少心绞痛发作次数、硝酸甘油消耗量,运动至出现ST段压低1mm所需时间、心绞痛所需时间、ST段缺血型下移之和明显减少,运动持续时间显著延长。结论阿托伐他汀及多西环素均缓解稳定型心绞痛病人症状,改善运动诱发的心肌缺血,提高运动耐量,疗效相类似。

Objective To evaluate the efficacy of atorvastatin and doxycycline on exercise tolerance in patients with stable angina pectoris. Methods Sixty patients with normal lipoidemia provened coronary artery disease by angiographical were given atorvastatin or doxycycline for g wk randomly. Treadmill exercise testing was adopted to invesgate exercise tolerance before and after therapy. Results After atorvastatin or doxycycline treating, angina petoris attack frequency and consumption of nitroglycerin weekly were decreased obviously; the time for inducing angina and 0. lmv ST segment depression, the total exercise time and ~ST depression by exercise were improved obviously in both groups. The serum total cholesterol, triglyceride were decreased and HDL-Cholesterol level increased only in atorvastatin group. Conclusion Both atorvastatin and doxycycline have obvious anti-ischemic efficacy in patients with stable angina pectoris, improve myocardial ischemia and exercise tolerance induced by exercise. Atorvastatin improves lipid profile also.