钙与骨代谢和骨质疏松的关系

Relationship between osteoporosisand metabolism of calcium and bone

用代谢平衡、骨密度测量、动物骨质疏松模型病理学检查、骨细胞培养等方法研究人钙与骨代谢和骨质疏松。结果表明国人钙摄入量偏低，肠钙净吸收率近十余年来渐增。性激素不足和钙摄入不足是发生原发性骨质疏松的主要原因。

Using metabolic balance test, bone mineral density measurement, animal models of osteoporosis, bone cell culture, we investigated the relationship between osteoporosis and the metabolism of calcium and bone. We found that the calcium intake was rather low in 20 healthy adults (480mg per day); the average intestinal net absorption rate(%) of calcium in 124 healthy adult volunteers was 28.9(%), which increased gradually in recent 20 years (from 17.1% in 1978 to 40.6% in 1977), owing to improvement of dietetic structure. We conclude that the insufficiency of sex hormone and calcium are the main casuses of osteoporosis. In bone cell culture, the whole process of bone remodelling was observed for 35 days continuously. Calcitonin damaging osteoclast was also investigated. Thus, we suggest new concept of bone remodelling coupling.