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(R)-(-)-4-氰基-3-羟基丁酸乙酯的制备 被引量：3

Preparation of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
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摘要 (S)-(-)-环氧氯丙烷经氰化钠开环得到(S)-4-氯-3-羟基丁腈,用乙醇醇解得到(S)-4-氯-3-羟基丁酸乙酯,再经三甲硅烷基保护、氰化钠氰化、脱除保护基,得到阿伐他汀关键中间体(R)-(-)-4-氰基-3-羟基丁酸乙酯,总收率约57%。 Ethyl （R）-（-）-4-cyano-3-hydroxybutyrate was synthesized from （S）-（-）-epichlorohydrin by ring-opening with sodium cyanide to form （S）-4-chloro-3-hydroxybutyronitrile, which was subjected to alcoholysis, protection of hydroxyl group with hexamethyl disilazane, cyanidation and then deprotection with hydrochloric acid. The total yield was 57%.
作者 洪华斌 蒋成君
机构地区 浙江新东港药业股份有限公司 浙江科技学院生物与化学工程学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2009年第7期486-487,共2页 Chinese Journal of Pharmaceuticals
关键词 (R)-(-)-4-氰基-3-羟基丁酸乙酯 阿伐他汀 中间体 制备 ethyl （R） - （-） -4-cyano-3-hydroxybutyrate atorvastatin intermediate preparation
分类号 O623.76 [理学—有机化学]
  • 相关文献

参考文献6

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共引文献11

同被引文献25

  • 1章磊,徐兰霞,徐建国,张福利,郭振荣.四种治疗阿尔茨海默病药物的比较评价[J].世界临床药物,2013,34(1):59-63. 被引量：10
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引证文献3

二级引证文献10

中国医药工业杂志
2009年 第7期

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