非酒精性脂肪肝病患者血清对氧磷脂酶1水平及意义

The Significance of Serum Paraoxonase 1 Activity in Non-alcoholic Fatty Liver Disease

目的探讨对氧磷脂酶1(PON1)活性与非酒精性脂肪肝病的关系。方法以对氧磷为底物测定30例正常人、52单纯性脂肪肝患者、41例脂肪性肝炎患者、31例脂肪性肝硬化患者血清PON1活性。结果单纯性脂肪肝组、脂肪性肝炎组及脂肪性肝硬化组血清PON1活性分别为(153.41±13.34)、(108.72±16.17)、(98.90±13.05)U/L,均低于正常对照组(181.12±9.50)U/L,差异有统计学意义(P<0.01);脂肪性肝炎组、脂肪性肝硬化组PON1活性与单纯性脂肪肝组比较差异有统计学意义(P<0.05);脂肪性肝炎组PON1活性与脂肪性肝硬化组比较差异无统计学意义(P>0.05)。结论PON1活性与肝脏的受损害程度密切相关,在一定程度上可反映非酒精性脂肪肝的严重程度,同时PON1还可能是非酒精性脂肪性肝病受损害的因素之一。

Objective To explore the relationship between paraoxonasel activity and non-lcohol fatty liver. Methods Serum PON1 activity was measured by using paraoxon as substrate in 30 case of norm, 52 of simple fatty liver,41 of steatohepatitis and 31 of fatty liver cirrhosis. Results Serum PON1 activity was（153.41±13.34）U/L in simple fatty liver, （108. 72±16. 17）U/L in steatohepatitis and （98.90±13.05）U/L in fatty liver cirrhosis that was significantly lower than that in norm group（181.12±9.50）U/L（P〈0.01）. Serum PON1 activity in steatohepatitis and fatty liver cirrhosis group were lower than that in simple fatty liver（P〈0.05）. There were no difference between steatohepatitis and fatty liver cirrhosis groups（P〈0.05）. Conclusion Serum PON1 activity is correlated with the stage of non-alcoholic fatty liver disease and it may be one of damage factor in non-alcoholic fatty liver disease