卡介菌多糖核酸联合氯雷他定治疗儿童慢性荨麻疹的疗效观察

Clinical Observation of BCG-PSN Combined with Loratadine in Treatment of Chronic Urticaria in Children

目的观察卡介菌多糖核酸联合氯雷他定治疗儿童慢性荨麻疹的疗效和安全性。方法将100例儿童慢性荨麻疹患者随机分成两组,治疗组隔天臀部肌注卡介菌多糖核酸0.5ml及每天口服氯雷他定5mg,共4周;对照组每天口服氯雷他定5mg,共4周。结果治愈率治疗组81%,明显高于对照组60%,两组差异有显著性意义χ2=14.7,P<0.05。结论卡介菌多糖核酸联合氯雷他定治疗儿童慢性荨麻疹有较好的疗效。

Objective To determine the efficacy and safety of BCGPSN and loratadine in the treatment of chronic urticaria in children. Methods One hundred children with chronic urticaria were divided randomly into two groups, with fifty children each. The treatment group took intramuscular injection BCG- PSN 0.5 ml every other day and oral loratadine, 5 mg, once a day for four weeks. In the control group, only oral loratadine, 5 mg daily, was administrated for four weeks. Results The effective rate of the treatment group was 81%, while the effective rate of the control group was 60%. The difference between two groups was significant（X2=14.7, P〈0.05）. Conclusion Treatment of chronic urticaria in children by BCG-PSN combined with loratadin has a better curative effect.