复方鱼腥草片的体外溶出度研究

Study on Invitro Dissolution of Fufangyuxingcao Tablets

目的考察不同厂家(分别以代码A、B、C、D、E和F表示)生产的复方鱼腥草片的体外溶出度,为临床的选用提供参考。方法采用转篮法进行体外溶出度试验,以紫外分光光度法测定复方鱼腥草片的累积溶出度,并对不同厂家的复方鱼腥草片的体外溶出度进行多重比较。结果6个不同厂家的复方鱼腥草片体外溶出度有显著性差异(P<0.05),只有厂家B和E无显著性差异。结论有必要对各个厂家的溶出度进行检测,以确保临床疗效。

Objective The invitro dissolution of Fufangyuxingcao tablets from six different manufacturers （coded as A, B, C, D, E and F respectively） was determined. Methods The dissolution tests were carried out by basket-rotating method. The cumulative dissolution of Fufangyuxingcao tablets was determined by UV spectrophotometry and multiple-compared from different manufacturers. Results Six manufacturers differed significantly each other in their dissolution（P 〈 0.05）, except between B and D （P 〉 0.05） . Conclusion It is suggested that the dissolubility of tablets from different manufactures should be tested to control the quanlity and ensure the clinical effect.