脑利钠肽与小儿心血管疾病

Brain natriuretic peptide in children's cardiovascular diseases

脑利钠肽(BNP)是一种主要来源于心室的心脏内分泌激素,在脑利钠肽前体分泌过程中或进入血液后分解为无生物活性的N端片段(NT-proBNP)和具有生物活性的BNP。BNP具有利尿、利钠、扩张血管和拮抗肾素-血管紧张素-醛固酮系统等多种生物学作用。许多研究表明心血管疾病患儿的血浆NT-proBNP和BNP水平升高,且NT-proBNP和BNP反映心室功能,因此可应用于心血管疾病患儿的诊断和评估。

Brain natriuretic peptide （BNP） is a cardiac hormone mainly secreted by myocytes in the ventricular wall. It is synthesized as an inactive prohormone that is split into inactive N- terminal fragment （NT-proBNP） and active hormone BNP. BNP has a number of systemic effects, including increases in urinary volume and sodium output, vascular dilation and inhibition of the renin-angiotensin-aldosterone system. The increased levels of NT-proBNP and BNP have been reported in children＇s cardiovascular diseases in numerous studies and can reflect cardiac function. Therefore, NT-proBNP and BNP can be used to diagnose and evaluate children＇s cardiovascular diseases.