血浆孤啡肽水平与情感障碍的相关性研究

Relationship study between plasma orphanin FQ and affective disorder

目的探讨血浆孤啡肽（orphaninFQ，OFQ）水平与情感障碍的关系，为情感障碍的发病机制、诊断等寻找新的生物学指标。方法筛选71例情感障碍患者（单相抑郁组24例、双相抑郁组21例、双相躁狂组26例）和31例正常人，应用放射免疫法分别测定其血浆OFQ水平，比较病例组与对照组血浆OFQ水平，分析病例组OFQ水平与各量表总分的相关性。结果1．血浆孤啡肽水平：单相抑郁组为（17．20±4．13）ng／L，双相抑郁组为（20．16±3．58）ng／L，躁狂组为（11．29±3．28）ng／L，对照组为（13．92±4．53）ng／L。单、双相抑郁组OFQ水平明显高于对照组（t=2．76；t=5．28，均P〈0．01）；躁狂组OFQ水平明显低于对照组（t=2.47，P〈0．05）。2．单、双相抑郁组OFQ水平与汉密顿抑郁量表、蒙哥马利抑郁量表总分呈显著正相关（P〈0．05），躁狂组OFQ水平与Bech—Rafaelsen躁狂量表总分呈显著负相关（P〈0．01）。结论情感障碍患者血浆OFQ水平的变化可能参与情感障碍的发病机制并提示病情的严重程度。

Objective To investigate the pathogenesis and diagnosis of affective disorder through studying the changes of plasma orphanin FQ （OFQ） level in patients with affective disorder. Methods 24 patients with major depressive disorder（ MD group）,21 patients with Bipolar 11 depression（ BD group）,26 patients with Bipolar I mania （BM group） and 31 healthy volunteers（ control group）were studied. The concentrations of plasma orphanin FQ were measured by radioimmunoassay （RIA）. Results 1. The plasma OFQ concentration was （ 17.20 ± 4.13） ng/L in MD group, （20.16 ± 3.58）ng/L in BD group, （11.29 ± 3.28 ） ng/L in BM group and （13.92 ± 4.53） ng/L in control group. Compared with the control group, the levels of plasma OFQ in MD and BD group were higher（ t = 2.76, t = 5.28 ; P 〈 0. 01 ） ,while the level in BM group was lower （ t = 2.47, P 〈 0. 05 ）. The differences were statistically significant. 2. The levels of plasma OFQ in MD and BD group were positively correla- ted to HAMD and MADRS（ r = 0. 598, P 〈 0. 01 ; r = 0. 646, P 〈 0. 05 ）. And there was a significantly negative correlation between the OFQ level and BRMS in BM group（ r= -0.750, P〈0. 01）. Conclusion The changes of plasma OFQ level may play an important role in the pathogenesis of affective disorder and indicate the severity of disease.