含左氧氟沙星四联幽门螺杆菌补救治疗方案的疗效观察

Effective observation of the levofloxacin-based quadruple rescue therapy regimen in eradicating H. pylori

目的研究含左氧氟沙星的四联幽门螺杆菌补救治疗方案的疗效及安全性,探讨治疗幽门螺杆菌感染的安全、有效方案。方法选择消化性溃疡及慢性胃炎幽门螺杆菌感染患者进行过1次或多次H.pylori根除治疗、停用抗生素至少1个月、停用质子泵抑制剂至少2周、复查14C尿素呼气试验仍为阳性者41例,口服兰索拉唑,枸橼酸铋钾,左氧氟沙星,呋喃唑酮。观察其根除率、不良反应、症状缓解及溃疡愈合情况。结果41例患者中失访4例,幽门螺杆菌根除32例,意向性治疗分析根治率78.0%,符合方案治疗分析根除率86.5%;症状改善总有效率91.9%;不良反应发生率16.2%,无严重不良反应。结论含左氧氟沙星四联补救治疗方案是一安全有效治疗方法。

Objective Study of the levofloxacin - based quadruple rescue therapy was to discuss safe and effective. Methods Forty - one patients who had H. pylori eradication one or more times with chronic gastritis or peptic ulcer, stopping antibiotic at least one month, and PPI at least two weeks, but recent^14 C-Urea breath test （UBT） was still positive, were treated with the regimen： levofloxacin, furazolidone, bismuth potassium citrate, and lansoprazole for 7 days, The eradication rates, efficacy, and adverse reaction rates of the three regimens were observed. Results Eradication rates by intention -to -treat and per - protocol analyses were 78.0% and 86.5%, respectively. The total release rate of all symptoms was 91.9%. adverse reaction were slight and the adverse reaction rate was 16.2%. Conclusions The levofloxacin -based quadruple rescue therapy regimen was safe and effective.