准分子激光治疗白癜风的临床疗效与安全性研究

Efficacy and safety of 308 nm excimer laser in the treatment of vitiligo

目的探讨308nm准分子激光治疗不同类型及病期的白癜风的疗效和不良反应。方法对128例白癜风患者的317处皮损进行局部照射，每周1次，8次为1个疗程。每个疗程结束及治疗结束后对色素恢复程度进行评估，并记录不良反应。结果共治疗皮损317片，总体应答率为97．5％，有效率为71．3％，显效率为50．8％。色素恢复程度随着治疗次数增加而增加。面颈部疗效优于躯干四肢，躯干四肢优于肢端部位。短病程（〈1年）的白癜风皮损疗效优于长病程（≥1年）的皮损。成人和儿童、活动期和稳定期的皮损疗效无明显差异。患者耐受性较好。结论308nm准分子激光治疗白癜风起效快，疗效及依从性好，不良反应少。

Objective To assess the efficacy and safety of 308 nm excimer laser in the treatment of different types of vitiligo at different stages. Methods A total of 128 patients with vitiligo, who had 317 depigmented patches, were recruited in this study and treated with 308 nm excimer laser once a week for at least 8 weeks. The degree of repigmentation was evaluated and adverse effects were recorded at the end of every treatment and last treatment. Results All patients received efficacy and safety evaluation. Of the 317 patches, 97.5% achieved repigrnentation at different degrees, 71.8% got more than 25% repigmentation, and 50.8% got more than 75% repigmentation. The degree of repigmentation increased with the number of treatments. A better response was observed in the lesions on the face and neck than those on the trunk and limbs, and in short-duration （〈1 year） lesions than in long-duration （≥ 1 year） lesions. And the lesions on extremities and mucosa showed a poorer response compared with those at other sites. There was no statistical difference in clinical efficacy between active vitiligo and stable vitiligo, or between adults and children. Moreover, the treatment was well tolerated. Conclusion 308 nm excimer laser is effective in the treatment of vitiligo with rapid onset, favorable tolerability and few adverse effects.