活性氧簇在皮炎湿疹发病中的作用

Effect of reactive oxygen species in the pathogenesis of eczema and dermatitis

活性氧簇是重要的氧的衍生物，氧化还原反应状态的平衡对维持机体的内环境起着重要的作用。皮肤是氧应激损害的主要靶器官，过多活性氧造成组织损伤，其主要通过影响核因子-κB、NO、蛋白激酶介导的磷酸化和基因异常表达发挥作用。多种炎症性皮肤疾病与活性氧簇相关，活性氧簇在皮炎、湿疹的发病中起着重要作用，抗氧化剂有望成为治疗这类疾病的新途径。

Reactive oxygen species （ROS） are important oxygen derivatives, and redox state plays a vital role in maintaining the balance of internal environment of the body. Skin has become a major target organ in oxidative damage. Overproduction of ROS can damage skin tissue. It is through affecting the phosphorylation and gene expression mainly mediated by nuclear factor-kappa B, nitrogen monoxidum, and protein kinases that ROS play their pivotal role in cutaneous pathophysiology. Many inflammatory skin diseases are associated with ROS, and ROS are reported to play an important role in the pathogenesis of dermatitis and eczema. Antioxidants are expected as a new approach to the treatment of this kind of diseases.