富含半胱氨酸的酸陛分泌糖蛋白与皮肤纤维化疾病

Secreted protein, acidic and rich in cysteine and fibrotic skin diseases

富含半胱氨酸的酸性分泌糖蛋白是纤维化疾病进程中的一个关键因素。体内外实验表明，其能影响多种细胞的活动，富含半胱氨酸的酸性分泌糖蛋白及其相关的肽与细胞外基质结合，影响细胞外基质的表达，改变细胞形态变化、降低细胞的黏附性、影响细胞的迁移、调节生长因子诱导的细胞增殖及血管发生。这些功能同纤维化的发生、发展密切相关。鉴于富含半胱氨酸的酸性分泌糖蛋白在多种纤维化疾病中的重要作用，概述其与系统性硬化病、创伤愈合及病理性瘢痕之间的关系及作用机制。

SPARC （secreted protein, acidic and rich in cysteine） is a key determinant of progressive fibrotic diseases. In vitro and in vivo studies have demonstrated that SPARC influences a variety of cellular activities. SPARC and its related peptides bind to several proteins of extracellular matrix （ECM）, affect ECM protein expression, alter cell shape, reduce cellular adhesion, influence cell migration, and modulate growth factor-induced cell proliferation and angiogenesis. It is closely related to the occurrence and progress of fibrotic diseases. In view of the important roles of SPARC in a variety of fibrotic diseases, this paper presents the relationship of SPARC to systemic sclerosis, wound healing and pathological scar and its mechanisms.