复方甘草酸苷联合丹参注射液治疗系统性硬皮病疗效观察

Observation of Therapeutic Efficacy of Stronger Neo-minophagen C Combined with Salvia Miltiorrhiza Injection on Treating Systemic Sclerosis

目的探讨复方甘草酸苷联合丹参注射液治疗系统性硬皮病的临床疗效。方法40例系统性硬皮病患者随机分为治疗组及对照组,治疗组20例予静滴复方甘草酸苷注射液40～60mL,丹参注射液20mL,1次/d。对照组20例仅予丹参注射液20mL静滴,1次/d。疗程均为4周。皮肤硬化程度采用改良的Rodnan评分法评估。结果治疗组治疗前后的Rodnan评分下降值(10.95±4.50)明显高于对照组(6.80±1.96)(P<0.01)。结论复方甘草酸苷联合丹参注射液治疗系统性硬皮病疗效较好。

Objective To study the therapeutic efficacy of stronger neo-minophagen C combined with salvia miltiorrhiza injection on treating systemic sclerosis. Methods 40 patients were divided into two groups respectively： 20 of them were treated with stronger neo-minophagen C 40 - 60mL combined with salvia mihiorrhiza injection 20mL once a day for 4 weeks, the other 20 patients in control were treated only with salvia miltiorrhiza injection 20mL once a day also for 4 weeks. Changes in the skin thickness were evaluated using the modified rodnan score. Results The rodnan score of treatment group dropped significantly more than that of control group（ P 〈 0.01 ）. Conclusions Stronger neo-minophagen C combined with salvia miltiorrhiza injection was effective in the treatment of systemic sclerosis patients and worth clinical application.