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维持性血液透析患者颈动脉钙化相关因素分析 被引量:10

Correlation Factors with Carotid Artery Calcification in Maintenance Hemodialysis Patients
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摘要 目的:探讨慢性肾衰竭维持性血液透析(MHD)患者颈动脉钙化情况并分析相关因素。方法:对35例MHD患者应用彩色B型超声仪观测双侧颈动脉内膜-中膜厚度(IMT)及钙化情况,同时记录透析龄、收缩压、脉压差,抽血检测血钙、磷、血胆固醇、三酰甘油、白蛋白、C反应蛋白(CRP)、甲状旁腺素,并计算钙磷乘积。结果:35例终末期肾病(ESRD)患者18例(51.4%)存在颈动脉钙化。钙化组IMT值较无钙化组显著增高(P<0.01),透析龄、收缩压、脉压差、血磷、钙磷乘积、CRP较无钙化组明显增高(P<0.05),而钙化组血浆白蛋白较无钙化组显著降低(P<0.05)。结论:IMT值、透析龄、血磷、钙磷乘积增高是颈动脉钙化的主要影响因素,收缩压、脉压差、CRP升高和低血浆白蛋白与颈动脉钙化密切相关。MHD患者存在较高的颈动脉钙化率。 Objective: To investigate prevalence and correlation factors of carotid calcification and in maintenance hemodialysis patients. Methods:The intimamedia thickness (IMT) and calcification degree of bilateral carotid artery were detected by ultrasonography in 35 maintenance hemodialysis (MILD) patients. Years on hemodialysis, systolic/pulse blood pressure, serum calcium/ phosphorus and its product, serum lipid profile, C- reaction protein(CRP), intact - parathyroid hormone(i - PTH) were checked at the same time. Results:Carotid calcification was confirmed in 18 of 35 MHD patients (51.4 % ). IMT( P 〈 0.01 ), years on hemodial- ysis, systolic/pulse blood pressure, serum calcium phosphorus product, CPR were significantly higher (P 〈 0.05 ) and serum albumin was significantly lower( P 〈0.05 ) in patients with carotid calcification than those in patients without carotid calcification. Conclusion: IMT, years on hemodialysis and serum calcium phosphorus product were main influential factors of carotid calcification in MHD and systolic/pulse blood pressure, higher CRP level, lower serum albumin were closely correlated with carotid calcification. Carotid calcification was very prevalent in MHD patients.
出处 《中国中西医结合肾病杂志》 2009年第7期610-612,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 深圳市科技计划项目(No.200903047)
关键词 慢性肾衰竭 血液透析 动脉钙化 危险因素 颈动脉超声 Chronic renal failure Hemodialysis Artery calcification Risk factor Carotid ultrasonography
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