隆乳术后乳腺癌临床病理观察

Breast carcinoma after augmentation mammoplasty:a clinicopathologic observation

目的探讨隆乳术后乳腺癌的临床病理学特征、诊断及鉴别诊断。方法结合文献回顾分析2例隆乳术后乳腺癌临床资料、病理学形态和免疫组化标记结果。结果2例女性隆乳（奥美定注射）患者的右乳腺肿物病理诊断为浸润性导管癌,其中1例组织学分级Ⅱ级,另1例为具髓样癌特征的浸润性导管癌。光镜下见癌细胞巢之间或肿物边缘有淡蓝色均匀一致的黏液样隆乳填充物,周围可见异物巨细胞、组织细胞、淋巴细胞和浆细胞浸润。其中例1腋窝淋巴结见癌转移。结论隆乳与乳腺癌的发生是否相关联尚待证实,但隆乳并发乳腺癌容易误诊,确诊依靠组织活检。隆乳术后乳腺癌有其较特异的病理学特征。

Objective To study the clinicopathologic features, diagnosis and the differential diagnosis of breast carcinoma after augmentation mammoplasty. Metthods The clinical, pathologic and immunohistochemical features were reevaluated in 2 cases. Results Two cases of female breast augmentation mammoplasty （Orimeten injection） patients were pathologically diagnosed as invasive ductal carcinoma, one case was basaloid carcinoma with histological grade Ⅲ, and the other grade Ⅱ . The pathological examination showed that some light blue uniform mucoid breast augmentation fillers were found between the cancer nests or the edge of tumors, surrounded hy infiltration of foreign body giant cell, histiocyte, lymphocyte and plasmocyte. Axillary lymph node metastases were detected in one case. Conclusions The association of augmentation mammoplasty with breast cancer has not been established yet, but augmentation mammoplasty with breast cancer is easily misdiagnozed. The diagnosis can be confirmed by biopsy. Breast cancer after augmentation mammoplasty presents specific pathological features.