解毒活血方案对颈动脉粥样硬化血流动力学影响的探讨

Hemodynamic effects of toxin-resolving and blood-activating in carotid atherosclerosis

目的：观察解毒活血配伍方案对颈动脉粥样硬化血流动力学的影响。方法：入选颈动脉粥样硬化患者120例，随机分为4组，即A组（解毒组）、B组（活血组）、C组（解毒活血配伍组）、D组（洛伐他汀对照组），疗程6月。采用高分辨力超声技术观察治疗前后颈动脉血流动力学改变。结果：解毒活血配伍组提高PSV、EDV、PI，降低RI的疗效优于单纯解毒组、活血组及洛伐他汀组，可显著改善颈动脉血流动力学，从而稳定颈动脉粥样硬化斑块。结论：解毒活血配伍具有稳定颈动脉粥样硬化斑块的作用，疗效优于单纯解毒、活血及洛伐他汀组。

Objective： To observe the hemodynamic effects of toxin-resolving and blood-activating in carotid atherosclerosis. Methods： One hundred and twenty patients of carotid atherosclerosis were divided into 4 groups randomly： A group （toxin-resolving group）, B group （blood-activating group） ,C group （toxin-resolving and blood activating group） and D group （lovasta tin group） . The course of treatment was six months. Hemodynamic changes were observed by high resolution ultrasound. Results： Compared to other groups, EDV, Vm and PI were significantly increased while RI was significantly decreased in C group, which showed the principle of toxin resolving and blood activating could improve hemodynamic indexes and stabilize carotid atherosclerotic plaque. Conclusion： The principle of toxin resolving and blood activating can stabilize the carotid atherosclerotic plaque, which are superior to toxin resolving or blood-activating.