山楂胃石成因的离体和自体实验研究

Experimental study about the causes of bezoar composed of hawthorn

目的：探讨山楂胃石的形成机制。方法：将新鲜的胃液、稀盐酸、蒸馏水及碳酸氢钠溶液加入经咀嚼或人工捏碎揉合的成熟或不成熟山楂团，进行11组不同的体外实验。笔者3次空腹食入鲜山楂行体内实验，并行X线追踪观察。结果：山楂团在酸性甚至中性实验液中，15 min内即可凝结成块，而在碱性实验液中有崩解现象。体内实验见胃内多发性活动性充盈缺损，十二指肠壶腹部及空肠亦可出现充盈缺损征象。结论：山楂酸的凝聚性是形成山楂胃石的内在因素；酸性胃液是形成山楂胃石的生化内环境；空腹食入不成熟的鲜山楂、胃排空减慢的各种因素是其形成的重要外因；饮酒和浓茶可刺激胃酸分泌，对胃石的形成有促进作用。

Objective： To investigate the mechanism of bezoar composed of hawthorn. Methods： An invitro study in eleven groups was performed with gastric juice, dilute hydrochloric acid, distilled water and solution of baking soda combined with the mass of hawthorn. An invivo study （three times） was performed by the author who has ingested hawthorns. The signs were observed through X-ray. Results： The mass of hawthorn could be coagulated in the acid and neutral solution within 15 min, but it could be disintegrated in the alkaline solution. Multiple and active filling defect could be found in stomach and duodenal bulb. Conclusion： The conglutination of cralaegolic acid is the immanent factor of bezoar, acid gastric juice is the internal environ ment,the immature hawthorn and the different factors of gastric emptying are the important exogenous factors, alcohol and strong tea can promote the formation of bezoar.