针药结合机制研究概况的分析及思考

Review on the Mechanism of Joint Application of Acupuncture Therapy and Medication in Clinical Practice

针药结合是针刺和药物两种治疗方式的有机组合,临床使用广泛,机制研究也日趋深入。本文从神经调节、内分泌调节、免疫调节3个方面回顾了近10年来针药结合的机制研究,并在此基础上进行了分析探讨,认为针药结合疗法的增效机制可能涉及以下3个方面:①针刺穴位可能通过影响血清药物浓度的改变,从而介导针刺对药物的增效作用;②穴位针刺能够特异性地引起与其相关联的内脏靶器官对于靶向性药物的吸收增加;③穴位针刺特异性地提高了靶器官对该药物的反应性或敏感性。

Acupuncture therapy combined with medication has been widely used in clinic practice in China and proved to be effective in the treatment of many disorders. The authors of the present paper review researches on the underlying mechanism of joint application of acupuncture therapy and medication in recent decade from 1）neural regulation, 2）endocrine regulation, and 3） immunological regulation. After comprehensive analysis, the authors think that the mechanism underlying the enhanced clinical efficacy of acupuncture therapy combined with drugs may be closely associated with the following factors： 1 ） acupuncture stimula- tion of acupoints leads to changes of the drug concentration in the blood and/or in the target organ and, 2） the reactivity or sensitivity of the target organ tissues to the specifically effective drug elements is enhanced.