摘要
Gap junction is one kind of synapse coexisting with chemical synapse in the nervous system. Nowadays with the development of electrophysiological technique,more research began to focus on the role of gap junction in the neural network,especially in the cognitive function. Gap junction collaborates with chemical synapses to induce the neural network activities related to memory and perception,such as gamma and ripple oscillation,which is regarded as the mechanism of the role of gap junction in cognitive function. This review introduces the structure of gap junction,distribution and expression of different kinds of connexins in central nervous system,which are the basic element of gap junction. Furthermore,this review discusses the role of gap junction in cognition related network oscillations and activity-dependent plasticity of gap junction.
Gap junction is one kind of synapse coexisting with chemical synapse in the nervous system. Nowadays with the development of electrophysiological technique, more research began to focus on the role of gap junction in the neural network, especially in the cognitive function. Gap junction collaborates with chemical synapses to induce the neural network activities related to memory and perception, such as gamma and ripple oscillation, which is regarded as the mechanism of the role of gap junction in cognitive function. This review introduces the structure of gap junction, distribution and expression of different kinds of connexins in central nervous system, which are the basic element of gap junction. Furthermore, this review discusses the role of gap junction in cognition related network oscillations and activity - dependent plasticity of gap junction.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2009年第7期1447-1450,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.30670750)
关键词
缝隙接合部
认知
突触
Gap junctions
Cognition
Synapses
