短纯音诱发的听性脑干反应测试中声诱发短潜伏期负反应研究

Study of Acoustically Short Latency Negative Response in Tone Burst Auditory Brainstem Responses

目的总结在有听力损失儿童中行短纯音诱发的听性脑干反应（tbABR）测试时记录到的声诱发短潜伏期负反应（acoustically short latency negative response,ASNR）的特点。方法在有听力损失的0-6岁儿童中应用SmartEP听觉诱发电位仪记录短声和短纯音ABR的反应阈,在记录到ASNR的受试者中分析其反应阈和潜伏期。结果在所有80受试耳中共7耳（8.75%）在cABR测试中引出ASNR,40耳（50%）在tbABR测试中引出ASNR,其中1 kHz引出率最高（37耳,46.25%）,2 kHz次之（25耳,31.25%）。引出ASNR者ABR波V反应阈最低65 dB nHL,ASNR反应阈最低80 dB nHL。0.5、1、2和4 kHz短纯音诱发的ASNR潜伏期分别为6-8、5-7、3-5、3-4 ms。随刺激强度的增加,其潜伏期缩短。结论有听力损失的儿童tbABR测试中可以记录到AS-NR,但不影响以波V反应阈评估听力。

Objective To study the characteristic of acoustically short latency negative response（ASNR） in auditory brainstem response（ABR） evoked by tone burst in children with hearing loss.Methods ABRs to click and tone burst were recorded from 06 years old children with hearing loss using SmartEP auditory evoked potential system.The threshold and latency was analyzed if ASNR was recorded.Results Among all the 80 ears tested,ASNR were recorded in 7 ears（8.75%） when using click,and in 40 ears（50%） when using tone burst.ASNR was most frequently evoked by 1 kHz tone burst（in 37 ears）,and 2 kHz（in 25 ears） was the second.Among the ears with ASNR,the lowest threshold of ABR wave V was 65 dB nHL.The lowest threshold of ASNR was 80dB nHL.The latencies of ASNR for 0.5,1,2 and 4 kHz tone burst was 68,57,35 and 34 ms,respectively.The latency decreased along with the increase of intensity.Conclusion ASNR can be recorded while recording tone-burst ABR,but it has no effect in predicting hearing level using the wave V threshold of tone-burst ABR.