新生儿窒息血浆中NT-proBNP的水平及临床应用

Plasma NT-proBNP level of neonates with neonatal asphyxia and clinical application

目的:探讨窒息新生儿血浆氨基末端脑钠肽前体(NT-proBNP)水平及临床意义。方法:选择用Apgar评分法诊断新生儿窒息,轻度组患儿54例、重度组49例、正常对照组(健康对照组)50例采用化学发光方法分别检测血浆NT-proBNP。结果:窒息组出生3天内血浆NT-proBNP水平显著高于对照组中出生3天内者的水平;重度窒息组血浆NT-proBNP显著高于轻度窒息组,与对照组比较有统计学意义;轻度窒息组血浆NT-proBNP明显高于健康对照组。结论:新生儿窒息血浆中氨基末端脑钠肽前体(NT-proBNP)的水平与新生儿窒息的程度成正比关系。

Objective： To explore the plasma N - terminal pro - brain natriuretic peptide （ NT - proBNP） level of neonates with neonatal asphyxia and its clinical significance. Methods： Apgar score was used to diagnose neonatal asphyxia, the levels of NT - proBNP in plas- ma from 54 cases of mild neonatal asphyxia, 49 cases of severe neonatal asphyxia and 50 healthy neonates were detected by chemiluminescent method. Results： For the neonates born within 3 days, the level of NT - proBNP in plasma in neonatal asphyxia group was significantly higher than that in control group; and the level of NT - proBNP in plasma in severe neonatal asphyxia group was significantly higher than that in mild neonatal asphyxia group. Conclusion： There is positive correlation between the NT - proBNP level and the degree of neonatal asphyxia.