维库溴铵的合成工艺改进

Improved synthesis of vecuronium bromide

以表雄酮为原料经磺酸酯化、消去、酯化、氧化、开环、还原、乙酰化,最后和溴甲烷成盐等8步反应合成维库溴铵,操作简捷、条件温和、成本低,适合工业化生产,产品结构经红外光谱、核磁共振谱、质谱确证,总收率19.6%。

Vecuronium bromide was synthesized from epiandrosterone through esterification, elimination, oxidation, ring opening, reduction, and acetylation, followed by reaction with bromomethane. This cost-saving and simplified method can be used in the commercial scale manufacture. The structure of this product was elucidated by IR, ^1HNMR, ^13CNMR, DEPT and MS, with an overall product yield reaching 19.6%.