肥胖相关性高血压

Obesity-Associated Hypertension

肥胖患者中枢及外周神经系统的异常在高血压的发生和发展起着非常重要的作用,但是,一些调节食欲和代谢的作用机制的阐明,有可能为治疗肥胖相关性高血压提供新的思路。在这些新发现包括:瘦素信号转导机制及瘦素抵抗机制;生长素和肽YY调节饥饿和饱食的信号传导机制;视黄醇结合蛋白在肥胖和胰岛素抵抗等疾病中的作用机制。这些新的发现可能会有助于肥胖相关性高血压的治疗。

Several central and peripheral abnormalities that can explain the development, or maintenance of, high arterial pressure in obesity have been identified. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of the leptin signaling pathway in the hypothalamus and the mechanisms of leptin resist- ance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for the treatment of obesity, and its subsequent complications. These recent discoveries should lead to novel strategies for the treatment of obesity and hypertension.