急性心肌梗死再灌注后无再流现象的研究进展

Advances in No-Reflow Phenomenon

急性心肌梗死再灌注后无再流现象是预后不良的独立预测因子,近年来,有斑块切除及远端保护装置、扩血管、抗血小板、改善内皮功能、抑制白细胞黏附、减轻再灌注损伤等多种治疗方法用于无再流的防治,但无再流现象并未得到完全解决。现就无再流现象的概念、发生机制及防治研究进展做一综述。

The no-reflow phenomenon after reperfusion in patients with acute myocardial infaretion is an independent predictor of a poor prognosis. In recent years various therapeutic strategies have been used to deal with no-reflow such as： plaque removal and distal protection devices, vasodilators, anti-platelet agents, improving endothelial function, leukocyte adhesion inhibition, and reperfusion injury reduction. The no-reflow phenomenon, however, has not been fully resolved. This review is focused on the det^nition and recent advances on the mechanism of, and the management of, the no-reflow phenomenon.