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胞外高迁移率族蛋白B1与缺血/再灌注损伤的关系 被引量：3

Research Progress on Effect of High Mobility Group Box 1 and the Relationship with Ischemia-reperfusion Injury
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摘要 诸多研究发现胞内高迁移率族蛋白B1（HMGB1）可以通过活化细胞的主动分泌和受损坏死细胞的被动释放进入胞外并介导炎性反应，为一种重要的炎性介质和促炎细胞因子。近年，HMGB。在缺血／再灌注损伤中的作用受到关注，许多研究结果显示，HMGB1在肝脏、肾脏、心脏等缺血再灌注损伤中发挥重要作用，本文就有关研究进展予以综述。 Much evidence has shown that high mobility group box 1 （ HMGBl ） as an important proin- flammatory mediator and cytokine can be released from activated cells and necrotic or damaged cells into extrecellular medium, and results in inflammatory response. Recently, effect of HMGB1 on ischemia-reperfusion injury comes to being attentioned. Many research results indicated that HMGB1 played an important role in ischemia-reperfusion injury of liver, kidney and heart. This article reviews the research progress about effect of high mobility group box protein 1 on ischemia-reperfusion injury.
作者 刘秋影 陈国千
机构地区 无锡市人民医院医学检验科
出处 《医学综述》 2009年第15期2259-2261,共3页 Medical Recapitulate
基金 江苏省自然科学基金(BK2006027)
关键词 胞内高迁移率族蛋白B1 炎性介质 缺血/再灌注损伤 HMGB1 Proinflammatory mediator Ischemia-reperfusion injury
分类号 R364.5 [医药卫生—病理学]
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参考文献20

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共引文献59

同被引文献35

  • 1臧益民,樊荣.加强多学科协作,争取心血管病研究取得新进展[J].心脏杂志,2006,18(5):483-488. 被引量：24
  • 2姜慧卿,姚希贤.肝星状细胞的活化与肝纤维化[J].胃肠病学和肝病学杂志,2007,16(1):86-89. 被引量：13
  • 3Herold K, Moser B, Chen Y, et al.Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress[J].J Ieukoc Biol, 2007, 82(2):204-201.
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引证文献3

二级引证文献8

医学综述
2009年 第15期

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