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AQP-4与创伤性脑水肿 被引量：2

AQP-4 and Brain Edema in Traumatic Brain Injury
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摘要 水通道蛋白4（AQP-4）是脑组织内高表达的一种水通道蛋白，主要表达于星形胶质细胞和室管膜细胞，尤其在与毛细血管和软脑膜直接接触的星形胶质细胞表达丰富，是参与脑水肿形成的重要分子，在水分子快速跨膜转运中发挥重要作用。最近研究表明，AQP-4在创伤性脑水肿的病理生理变化中发挥重要的作用。深入研究AQP-4与创伤性脑水肿之间的关系，将可能为临床治疗脑水肿提供新的思路和途径。 Aquaporin-4（ AQP-4 ）,a water-channel protein, is highly expressed in the brain, mainly expressed in astrocytes and ependymal ceils, especially in the astrocytes directly contacting with capillaries and cerebral piamater,which is an important element in the formation of brain edema and plays an important role in the rapid transmembrane transport. Recent investigations revealed that AQP-4 played an important role in brain edema during traumatic brain injury. Further research on the relation between AQP-4 and brain edema in traumatic brain injury may lead to new approaches for the treatment of brain edema.
作者 耿艺 刘荣耀
机构地区 大连医科大学附属第一医院神经外科
出处 《医学综述》 2009年第15期2261-2264,共4页 Medical Recapitulate
基金 辽宁省教育厅高等学校科研基金(05L110)
关键词 水通道蛋白-4 脑水肿 脑损伤 Aquaporin-4 Brain edema.. Brain injury
分类号 R651.15 [医药卫生—外科学]
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参考文献25

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同被引文献19

  • 1Wang Y,Tajkhorshid E.Nitric Oxide Conduction by the BrainAguaporin AOP4[J].Proteins,2010,78(3):661-670.
  • 2Strand L,Moe SE,Solbu TT,et al.Roles of aguaporin-4 isoformsand amino acids in square array assembly[J].Biochemistry,2009,48(25):5785-5793.
  • 3Liu Z,Liu Q,Cai H,et al.Calcito nin gene-related peptide preventsblood-brain barrier injury and brain edema induced by focalcerebral ischemia reperfusion[J].Regul Pept,2011,171(1-3):19-25.
  • 4Shin JA,Choi JH,Choi YH,et al.Conserved aquaporin 4 levelsassociated with reduction of brain edema are mediated by estrogenin the ischemic brain after experimental stroke[J].BiochimBiophys Acta,2011,1812(9):1154-1163.
  • 5Ding T,Ma YJ,Li WL,et al.Role of aguaporin-4 in the regulationof migration and invasion of human glioma cells[J].Int J Oncol,2011,38(6):1521-1531.
  • 6Lukaszewicz AC,Oyer B.Sodium and water balance and theinjured brain[J].Curr Opin Anaesthesiol,2011,24(2):138-143.
  • 7Oliva AA,Kang Y,Truettner JS,et al.Fluid-percussion brain injuryinduces changes in aquaporin channel expression[J].Neuroscience,2011,28(180):272-279.
  • 8Shi WZ,Zhao CZ,Huang XQ,et al.Deficiency of water channelAOP4 aggravates NMDA-induced brain injury in mice[J].Zhejiang Da Xue Xue Bao:Yi Xue Ban,2011,40(2):145-149.
  • 9Wang GH,Jiangz L,Li Yc,et a1.Free—radical scavenger edaravonetreatment confer sneumprot ection againsttraumatic braininjuryinrats[J].J Neurotrauma,2011,28(10):2123-2134.
  • 10Mdici V,Frassom C,Tassi L,et a1.Aquaporin 4 expwssion in controland epileptic human cerebral ColJex[J].Brain Res,2011,1367:330-339.

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医学综述
2009年 第15期

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