摘要
DNA甲基化是非DNA序列变化所致的基因修饰作用，这种基因修饰作用可在细胞分裂中进行遗传并影响DNA和其他分子的相互作用。DNA甲基化发生在CpG双核苷酸序列内，其5’端的胞嘧啶环在复制完成后添加一个甲基，导致DNA结合蛋白结合的部位即DNA双螺旋凹槽的外形发生改变。DNA甲基化不但与肿瘤的发生有关，还与许多其他疾病如动脉粥样硬化、糖尿病、阿尔茨海默病等相关联。本文对DNA甲基化与非肿瘤性疾病的关系予以综述。
DNA methylation is a kind of gene modification, which may be inherited in cell division and affect the interaction of DNA. DNA methylation is the postreplication addition of methyl groups to the 5 ＇-position of cytosine rings within the context of CpG dinucleotides, resulting in alterations in the appearance of the major groove of DNA to the position that DNA binding proteins bind. DNA methylation is associated with the progression of tumor, and is also correlated with non-neoplastic diseases, such as athero- sclerosis, diabetes mellitus , Alzheimer disease and so on. This article reviewed the relationship between DNA methylation and non-neoplastic diseases.
出处
《医学综述》
2009年第15期2270-2272,共3页
Medical Recapitulate
