强迫症药物治疗的研究进展

Research Development in Drug Treatment of Obsessive-Compulsive Disorder

强迫症是以无法控制的强迫思维和强迫动作为特征的神经症性障碍。近几年来临床上对强迫症的治疗作了大量的研究，并取得了长足的进展。大量的临床研究证实，除了氯米帕明对强迫症有效以外，SSRI类药物如博乐欣、氟西汀、舍曲林、帕罗西汀等对强迫症同样有效，且不良反应较氯咪帕明低，此类药物目前已经作为治疗强迫症的首选药物；此外喹硫平、利培酮等非典型抗精神病药物对抗强迫药物也起到了增效的作用。SSRIs＋神经阻滞剂是当前难治性强迫症治疗最有希望的方法之一。

The obsessive-compulsive disorder are neural disorders characterized as forced thinking and forced movement beyond control. In recent clinical treatment, the obsessive-compulsive disorder has been made a lot of researches and gained great progress. A large number of clinical studies confirmed that SSRI drugs such as venlafaxine, fluoxetine, sertraline, paroxetine were effective for obsessive-compulsive disorder in addition to clomipramine, and adverse reactions were lower than clomipramine, these drugs are now the first choice to treat obsessive-compulsive disorder; the quetiapine, risperidone and other atypical antipsychotics drugs also played a role to anti-forced drugs. SSRIs ＋ nerve blockers is the the most premising method to treat the refractory obsessive-compulsive disorder.