中医药多途径联合治疗慢性乙型重型肝炎的临床研究

Clinical Study on Patients with Chronic Severe Hepatitis B Treated by Traditional Chinese Medicine in Multichannel

目的:观察中医药多途径联合治疗慢性乙型重型肝炎的临床效果。方法:将55名慢性乙型重型肝炎(早、中期)随机分为对照组27例,治疗组28例,两组均采用基础西医治疗,治疗组加用甘露消毒丹辨证加减、丹参粉针并中药灌肠,观察不同治疗方案对其临床症状、生化指标及凝血酶原活动度的影响。结果:治疗组总有效率71.43%(20/28),显效率39.29%(11/28),对照组分别为51.85%(14/27)、14.81%(4/27),两组比较显效率差异有统计学意义(P<0.05)。治疗组与对照组均可改善转氨酶及凝血酶原活动度(PTA),治疗组在降低胆红素(TBil、DBil)及升高PTA方面有统计学意义(P<0.05,PDBil<0.01)。结论:中医药多途径联合治疗慢性重型肝炎,可更好的消退黄疸,改善凝血酶原活动度。

Objective：To observe the therapeutic effect on chronic severe hepatitis B treated by Traditional Chinese Medicine （ TCM ）in multieharmel. Methods ：55 patients with chronic severe hepatitis B in earlier period and metaphase were randomly divided into control group of 27 eases and treatment group of 28 eases. Both groups adopted the treatment of basis western medicine. Additionally, the treatment group was treated with Detoxification Pill by differentiation of symptoms and signs, Radix Salviae Milti- orrhiae powder acupuncture and Chinese herbs enema. To observe the effect on clinical symptoms, biochemical indicators and prothromhin activity with different treatment. Results ： The total effective rate and marked improving rate in the treatment group was 71.43% （20/28 eases） and 39. 29% （ 11/28 cases ） respectively, while those in the control group, 51.85% （ 14/27eases ） and 14. 81% （4/27 eases） respectively. The marked improving rate was showed significant difference between the two groups （P 〈 0. 05 ）. Both the treatment group and control group can improve aminotransferase and PTA; Compared with the control group, the treatment group can more effectively deserease TBil and DBil increase PTA （ P 〈 0. 05, PDBil 〈 0. 01 ）. Conclusion ： Treatment to chronic severe heoatitis B with TCM in multiehannel can validly regress Jaundice and imorove vrothrombin activity.