摘要
目的：研究中药复方克瘤丸对鸡胚尿囊膜（CAM）新生血管的抑制作用，进一步探讨克瘤丸抑瘤抗转移的机理。方法：以CAM为模型，观察克瘤丸3种不同提取法的提取物对CAM血管生长的抑制作用。结果：克瘤丸“组合提取法”取得的提取物对CAM血管生长的抑制最强，在5—10mg／mL浓度时对CAM血管形成具有显著的抑制作用（P〈0．01），并与浓度呈正相关。结论：克瘤丸具有显著抑制鸡胚尿囊膜血管生成的作用。
Objective：To study the mechanism of Ke Liu Wan on inhibition of growth and metastasis of tumor,we explored the effect of Ke Liu Wan on the angiogenesis in chick embryo chorioallantoic membrane （CAM）. Methods ： Ke Liu Wan were extracted by three methods,the effects of three extractions on vessel growth were observed by adopting CAM model. Results：The inhibitory efficiency of Ke Liu Wan extracted by“integrated extracted method”was the best ,it had remarkable inhibitory effect on the anglogenesis in CAM at the concentration of 5 - 10mg/mL（ P 〈 0.01 ） and the effect had positive correlation with concentration. Conclusion：Ke Liu Wan could remarkably inhibit the angiogenesis of CAM.
出处
《辽宁中医杂志》
CAS
北大核心
2009年第7期1230-1231,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
江苏省科技厅社会发展资助项目(BS2005074)
