摘要
A new method for synthesizing 2,6-dichlorodiphenylamine was presented in this article.2,6-dichlorodiphenylamine is the key intermediate for the preparing of diclofenac sodium.It was synthesized in a one-shot reaction with 2,6-dichlorophenol,a solution of sodium methoxide in methanol,methyl chloroacetate,aniline,and sodium hydroxide as raw materials by the acid-base neutralization,etherification,ammonolysis of ester,Smiles rearrangement of amide,and alcoholysis or hydrolysis of the rearrangement product.Based on many times of experiment,the best technological condition was found.The yield of target compound was about 91%.
A new method for synthesizing 2,6-dichlorodiphenylamine was presented in this article. 2,6-dichlorodiphenylamine is the key intermediate for the preparing of diclofenac sodium. It was synthesized in a one-shot reaction with 2,6-dichlomphenol, a solution of sodium methoxide in methanol, methyl chloroacetate, aniline, and sodium hydroxide as raw materials by the acid-base neutralization, etherification, ammonolysis of ester, Smiles rearrangement of amide, and alcoholysis or hydrolysis of the rearrangement product. Based on many times of experiment, the best technological condition was found. The yield of target compound was about 91%.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2009年第7期1079-1082,共4页
Chemical Research and Application
基金
安阳市科技局资助项目(07056)
