长期口服小剂量罗红霉素治疗鼻内镜鼻窦手术后迁延不愈的临床观察

Clinical observation of long-term low-dose oral roxithromycin treatment after endoscopic sinus surgery in patients with persistent illness

目的探讨长期口服小剂量罗红霉素治疗鼻内镜鼻窦手术后迁延不愈患者的疗效。方法对符合入选条件的53例鼻内镜鼻窦术后患者口服罗红霉素(150mg/d)3个月,停药后顺延随访3个月观察其疗效。结果按鼻内镜检查结果,术腔完全上皮化,无异常分泌物,窦口周边上皮化,窦口开放良好者15例(28.3%);术腔部分上皮化,有少量粘性分泌物,窦口呈开放状态22例(41.5%);术腔仍有明显水肿,无明显上皮化倾向,有息肉形成,水肿粘膜阻塞鼻窦开口或鼻窦口闭锁,窦腔粘连16例(30.2%)。结论罗红霉素作为十四元环大环内酯类药物有其很好的抗炎作用,对鼻内镜鼻窦术后迁延不愈的患者有很好的疗效。

Objective To investigate the long-term low-dose oral roxithromycin treatment after endoscopic sinus surgery in patients with persistent illness. Methods To comply with the conditions of the selected 53 cases of endoscopic sinus surgery in patients with oral roxithromycin （150mg/day） for 3 months, extended follow-up after stopping 3 months to observe its effect. Results According to the results of nasal endoscopy, epithelial cavity completely, and no abnormal secretions, ostium surrounding epithelium, and sinus mouth open well, 15 cases （28.3%）; epithelial cavity partly, and a small amount of viscous secretions, sinus mouth open, 22 cases（41.5%）; cavity is still obvious edema, no obvious tendency of epithelium, polyps formarion, sinus mucosa edema obstruction or sinus atresia, sinus adhesion, 16 cases （30.2%）. Conclusion Roxithromycin 14-membered macrolides as a drug have their good anti-inflammatory effects and good results on endoscopic sinus postoper- ative persistent illness.