妊娠合并宫颈上皮内瘤样变91例分析

Clinical Analysis on 91 Cases of Pregnancy Complicated by Cervical Intraepithelial Neoplasia

目的探讨妊娠合并宫颈上皮内瘤变(CIN)的治疗策略。方法对2004年6月～2006年6月期间在我院TCT有异常的患者91例进行宫颈多点活检、HPV分析、随访情况进行回顾性分析。结果妊娠期TCT异常患者活检提示,阴性37例(40.7%),CINⅠ41例(45.1%),CINⅡ10例(11.0%),CINⅢ3例(3.3%);分娩后1年内随访CIN好转的患者66例(72.5%),1年内未好转的患者25例(27.5%);在所有患者中HPV免疫组化的分析,其中阳性26例(28.6%)阴性65例(71.4%)。结论妊娠合并CIN患者处理不必过于积极,可采取期待疗法;HPV的检测对CIN的筛查有一定指导作用。

Objective To investigate the reasonable management of the pregnancy complicated by CIN. Methods Nninty-one cases of pregnant women complicated by CIN screened by TCT in our hospital from June 2004 to June 2006 were retrospectively analyzed based on their biopsy results, HPV detection results and follow up conditions. Results Among the pregnant women with abnormal TCT results, the biopsy showed 37 eases（40.7%） negative,41 cases（45.1%） of CIN I, 10 cases（ll.0%） of CIN Ⅱ ,3 cases （3.3%） of CINm. The follow-up with a year after delivery showed that 66 patients（72.5% ） recovered while 25 patients（27.5% ） did not. 26（28.6% ） patients were detected HPV positive by the immunohistochemieal method and 65 （71.40% ） patients were revealed to be HPV negative. Conclusion The Pregnancy complicated by CIN can be treated by expected therapy instead of active strategies; The detection of HPV is helpful for the screening of CIN.