摘要
The connexin 43 ( Cx43 ) proteins, which is the predominant protein that can form gap junctions and non- junctional hemichannels in ventricular myocardium, are central to the cardioprotection afforded by ischemic preconditioning (IP) and maybe ischemic postconditioning ( PC ) too. Recent studies showed that recruitment of Cx43 to the mitochondria in IP might play a role in the production of reactive oxygen species (ROS) that mediates IP. The localization of Cx43 at mitochondria appears to be important for the achieved cardioprotection and opens a new door for us to reveal the exact mechanisms of ischemia/reperfusion (I/R) injury and cardioprotection, and it might be new targets of pharmacological modulator to achieved cardioprotection.
The connexin 43 ( Cx43 ) proteins, which is the predominant protein that can form gap junctions and non- junctional hemichannels in ventricular myocardium, are central to the cardioprotection afforded by ischemic preconditioning (IP) and maybe ischemic postconditioning ( PC ) too. Recent studies showed that recruitment of Cx43 to the mitochondria in IP might play a role in the production of reactive oxygen species (ROS) that mediates IP. The localization of Cx43 at mitochondria appears to be important for the achieved cardioprotection and opens a new door for us to reveal the exact mechanisms of ischemia/reperfusion (I/R) injury and cardioprotection, and it might be new targets of pharmacological modulator to achieved cardioprotection.
基金
supported by the National Natural Science Foundation of China (No.30560051)
the Science Foundation for the Returned Over-seas Guangxi Scholars (No.0448014)
the Important Scientific Research Subject of Guangxi Medical Health (No.200301)