肺癌患者血清CEA、NSE及CYFRA21—1表达的意义

Expression of serum CEA, NSE and CYFRA21-1 versus the detection of lung cancer

目的分析血清CEA、NSE及CYFRA21—1水平在肺癌中的表达特点及其联合检测对于肺癌检测的临床意义。方法采用放射免疫法检测65例肺癌患者、50例肺部炎症患者和38名健康人血清中CEA、NSE、CYFRA21—1的水平。结果肺癌组CEA、NSE、CYFRA21-1肿瘤标志物水平显著高于肺炎组和健康对照组，差异有统计学意义（P〈0．01）。三项指标联合检测灵敏度及特异度高于单项指标检测。三项肿瘤标志物测定水平与病理类型有一定关系。结论血清CEA、NSE及CYFRA21-1水平在肺癌中高表达，且与病理类型有相关性。三者联合检测可提高肺癌的检出率。

Objective To investigate the expression of CEA, NSE and CYFRA21-1 in lung cancer, and the significance of combined determination of three tumor markers in the detection of lung cancer. Methods CEA, NSE and CYFRA21-1 levels in serum of 65 patients with lung cancer, 50 patients with benign lung diseases and 38 normal adults were measured by enzyme linked immunosorbent assay （ELISA）. The association of CYFRA21-1, NSE, and CEA level with the type of lung cancer in pathology were also studied. Results In comparison, the serum levels of CEA, CYFRA21-1 were increased more obviously in patients with lung cancer than that of patients with benign lung diseases and the normal adults （P 〈 0.01）. The levels of serum and the sensitivity of CEA, NSE and CYFRA21-1 were related to pathology type. The sensitivity and specificity increased by combined measurement of CEA, NSE, and CYFRA21-1. Conclusion These findings suggest that the serum CEA, NSE and CYFRA21-1 levels is increased in patients with lung cancer, and the increasing extents is not same in lung cancer with different pathology types. CEA, NSE and CYFRA21-1 are significant in adjuvant diagnosis of lung cancer.