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乙酰半胱氨酸对糖尿病大鼠心肌缺血/再灌注后低氧诱导因子-1α和血红素加氧酶-1基因表达的影响 被引量：4

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摘要 目的:观察乙酰半胱氨酸(NAC)对糖尿病大鼠心肌缺血/再灌注(I/R)后低氧诱导因子-1α(HIF-1α)和血红素加氧酶-1(HO-1)mRNA表达变化的影响。方法:用链脲佐菌素(STZ)复制糖尿病大鼠模型,动物分为正常假手术组(CS组)、正常I/R组(CI/R组)、正常I/R+NAC组(CN组)、糖尿病假手术组(DS组)、糖尿病I/R组(DI/R组)、糖尿病I/R+NAC组(DN组),每组12只,共72只。检测各组心肌梗死范围(IS/AAR)、HIF-1α和HO-1mRNA表达。结果:CS组检测不到HIF-1α和HO-1mRNA表达,DS组检测到少量HIF-1α和HO-1mRNA表达;DI/R组HIF-1α和HO-1mRNA表达低于CI/R组(P<0.05),IS/AAR大于CI/R组(P<0.05);DN组HIF-1α和HO-1mRNA表达高于DI/R组,但低于CN组(P<0.05);IS/AAR小于DI/R组,但大于CN组(P<0.05)。结论:NAC可部分恢复糖尿病大鼠心肌I/R后HIF-1α和HO-1mRNA表达,减小心梗面积,有一定的治疗效果。
作者 马利 杨艳 姚尚龙
机构地区 广西壮族自治区人民医院麻醉科 华中科技大学附属协和医院麻醉科
出处 《实用医学杂志》 CAS 北大核心 2009年第14期2232-2234,共3页 The Journal of Practical Medicine
基金 教育部留学回国人员科研启动基金资助项目[编号:教外司留(14)号]
关键词 心肌缺血 乙酰半胱氨酸 糖尿病 低氧诱导因子-1 血红素加氧酶-1 动物实验
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献9

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二级参考文献27

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共引文献47

同被引文献56

  • 1王志维,张凯伦,高尚志,涂仲凡,吴智勇.血管内皮生长因子定向转染诱导缺血心肌血管生成的研究[J].中华实验外科杂志,2006,23(7):844-846. 被引量：7
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实用医学杂志
2009年 第14期

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