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脂蛋白相关磷脂酶A_2与冠脉斑块炎症反应及病变程度的相关性 被引量：4

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摘要 目的:探讨冠心病患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)与冠状动脉炎症反应及其病变程度的关系。方法:59例经冠脉造影证实的患者纳入冠心病(CHD)组,其中稳定性心绞痛(SAP)17例,不稳定性心绞痛(UAP)25例,急性心肌梗死(AMI)17例,对照组30例为冠脉造影正常的非冠心病者。所有对象造影前采集血标本以检测Lp-PLA2、高敏C反应蛋白(hs-CRP)。结果:(1)冠心病组血浆Lp-PLA2、hs-CRP均高于对照组(P<0.01)。(2)AMI组与UAP组血Lp-PLA2、hs-CRP比较差异无显著性,但均高于SAP组(P<0.05);多支血管病变组血浆Lp-PLA2水平高于双支和单支血管病变组,双支血管病变组高于单支血管病变组(P<0.05)。(3)经双变量相关性分析,血浆Lp-PLA2水平与hs-CRP、Gensini积分水平呈显著相关(r=0.638,P<0.01;r=0.626,P<0.05)。结论:血浆Lp-PLA2水平能反映冠脉炎症活动性状况,与冠脉病变严重程度成正相关。
作者 李海云 高大胜
机构地区 安徽省蚌埠医学院第一附属医院心血管内科
出处 《实用医学杂志》 CAS 北大核心 2009年第14期2280-2281,共2页 The Journal of Practical Medicine
关键词 冠状动脉疾病 磷脂酶A 炎症反应
分类号 R541.4 [医药卫生—心血管疾病] R364.5 [医药卫生—病理学]
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参考文献8

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同被引文献28

  • 1Azambuja MI. Inflammation as the cause of coronary heart disease. Lancet Infect Dis, 2010;10:142-143.
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  • 10Robert S, Rosenson, Diana M, Stafforini. Modulation of oxidative stress, inflammation, and atherosolerosis by hpoprotein-associated phosphohpase A2. Journal of lipid research, 2012,53:1767 - 1782.

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实用医学杂志
2009年 第14期

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