摘要
世界卫生组织对男性不育的定义是:夫妇同居一年以上,未用任何避孕措施,由于男方因素造成的女方不孕。据报道,世界范围内约有15%-20%的育龄夫妇不能生育。传统的男性不育治疗主要包括药物治疗,手术治疗和辅助生殖技术治疗。近年来由于干细胞的再生潜力,使它成为治疗男性不育等退行性疾病的理想手段.本文主要对最近几年干细胞在男性不育领域的研究进展作一综述。
出处
《实用医学杂志》
CAS
北大核心
2009年第14期2388-2390,共3页
The Journal of Practical Medicine
参考文献22
-
1Serebrovska Z A,Serebroskaya T V,Pyle R L,et al.Transmission of male infertility and intracytoplasmic sperm injection[J].Fiziol ZH,2006,52(3):110-118.
-
2Toyooka Y,Tsunekawa N,Akasu R,et al.Embryonic stem cells can form germ cells in vitro[J].Proc Natl Acad,2003,100(20):11457-11462.
-
3Geijsen N,Horoschak M,Kim K,et al.Derivation of embryonic germ cells and male gametes from embryonic stem cells[J].Nature,2004,427 (6970):148-154.
-
4Hubner K,Fuhrmann G,Christenson L K,et al.Derivation of oocytes from embryonic stem cells[J].Science,2003,300(5623):1251-1256.
-
5Clark A T,Bodnar M S,Fox M,et al.Spontaneous differentiation of germ cells from human embryonic stem cell in vitro[J].Hum Mol Genet,2004,13(7):727-739.
-
6Kubota H,Avarbock M,Brinster R.Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells[J].Proc Natl Acad Sci,2004,101 (47):16489-16494.
-
7Nayernia K,Li M,Jaroszynski L,et al.Stem cell based therapeutical approach of male infertility by teratocarcinnoma derived germ cells[J].Hum Mol Genet,2004,13(14):1451-1460.
-
8Nayernia K,Nolte J,Michelmann H W,et al.In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice[J].Dev Cell,2006,11 (1):125-132.
-
9Braydich S L,Kostereva N,Dym M,et al.Role of src family kinases and N-myc in spermatogonial stem cell proliferation[J].Dev Biol,2007,304(1):34-45.
-
10Hofmann M C,Braydich-Stolle L,Dettin L,et al.Immortalization of mouse germ line stem cells[J].Stem Calls,2005,23(2):200-210.
同被引文献11
-
1戴美珍,钟倩怡,朱敏.染色体多态性与临床效应的探讨[J].中国优生与遗传杂志,2006,14(8):38-39. 被引量:22
-
2徐淑琴.男性不育患者200例染色体核型分析[J].实用医学杂志,2007,23(10):1544-1545. 被引量:5
-
3王小荣,邓剑霞,李津津.染色体多态性与临床效应及生殖关系的探究[J].遗传,2007,29(11):1362-1366. 被引量:109
-
4MehdiBenchaib, ValeArie Braun. Jacqueline Lomage,et al.SpermDNA fragmentation decreases the pregnancy rate in an assistedreproductive technique[J].Hum Reprod,2003,18 :1023-1028.
-
5OzmenB, Koutlaki N, Youssry M, et al. DNA damage of humanspermatozoa in assisted reproduction :origins, diagnosis,impactsand safety [J]. Reprod Biomed Online,2007,14 (3) :384- 95.
-
6SmithR,Kaune H, ParodiD, et al. Increased sperm DNA damagein patients with varicocele : relationship with seminal oxidativestress[J]. Hum Reprod,2006,21 (4) :986-993.
-
7杨丽霞,张琪瑶,孙伟,于庆.31例染色体多态性与生殖异常的关系[J].中国优生与遗传杂志,2008,16(4):38-39. 被引量:21
-
8张旸,顾莹,祝建疆,叶国玲.9号染色体多态性的细胞遗传学分析[J].中国优生与遗传杂志,2008,16(6):56-57. 被引量:19
-
9张颖,朱海燕,吴星,李洁,朱瑞芳.染色体多态性与不孕不育及自然流产关系的探讨[J].中国优生与遗传杂志,2008,16(11):28-29. 被引量:26
-
10李刚琴,何映.精子线粒体DNA损伤与男性不育[J].中国优生与遗传杂志,2010,18(4):4-5. 被引量:6
-
1史延超,张子州,郭志伟,李巧凤,杨海涛.中西医结合治疗男性不育症2046例临床观察[J].现代中西医结合杂志,2002,11(22):2228-2230. 被引量:9
-
2甄秀梅,乔杰.肥胖患者辅助生殖技术治疗[J].实用妇产科杂志,2011,27(5):329-330. 被引量:10
-
3林宏益,曲锡萍.辨证治疗男性不育398例疗效观察[J].河北中医,1986,8(3):10-12. 被引量:2
-
4邓旭辉,张荣华.中医药治疗男性不育症研究进展[J].现代中西医结合杂志,2008,17(33):5241-5243. 被引量:9
-
5贺占举,金杰.男性不育[J].中华临床医师杂志(电子版),2008,2(2):48-51. 被引量:1
-
6李静,武进峰,向鹏.显微外科在精索静脉曲张伴男性不育治疗中的应用[J].中国临床实用医学,2015,6(4):78-80.
-
7王云香.心理干预对辅助生殖技术治疗的不孕症患者焦虑及受孕情况的影响[J].广东医学,2015,36(4):653-654. 被引量:44
-
8张全军,彭德爱.锌硒宝在男性不育治疗中的应用[J].中华临床医药杂志(北京),2004,5(23):44-44.
-
9滕晓明,韩毅冰,黄文强,陈振文.男性不育的辅助生殖技术治疗[J].国际生殖健康/计划生育杂志,2012,31(5):378-380. 被引量:1
-
10周惠耕,江鱼.1321例男性不育症的病因分析和诊治体会[J].中国男科学杂志,1990,11(2):92-94. 被引量:5