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西妥昔单抗治疗进展性结直肠癌的疗效与KRAS基因突变状态的关系 被引量:7

KRAS Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
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摘要 1 文献来源 Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from Cetuximab in advanced colorectal cancer [J]. N Engl J Med, 2008, 359(17): 1757-1765.
作者 白春梅 黄凌
出处 《循证医学》 CSCD 2009年第3期144-146,149,共4页 The Journal of Evidence-Based Medicine
关键词 结直肠肿瘤 KRAS基因 西妥昔单抗 colorectal neoplasms KRAS gene Cetuximab
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参考文献6

  • 1Jonker DJ,O'Callaghan CJ,Karapetis CS,et al.Cetuximab for the treatment of colorectal cancer[J].N Engl J Med,2007,357(20):2040-2048.
  • 2Cunningham D,Humblet Y,Siena S,et al.Cetuximab monotherapy and Cetuximab plus Irinotecan in Irinotecanrefractory metastatic colorectal cancer[J].N Engl J Med,2004,351(4):337-345.
  • 3Sobrero AF,Maurel J,Fehrenbacher L,et al.EPIC:Phase Ⅲ trial of Cetuximab plus Irinotecan after Fluoropyrimidine and Oxaliplatin failure in patients with metastatic colorectal cancer[J].J Clin Oncol,2008,26(14):2311-2319.
  • 4van Cutsem E,Nowacki M,Lang I,et al.Randomized phase Ⅲ study of Irintoecan and 5-FU/FA with or without Cetuximab in the first-line treatment of patients with metastatic colorectal cancer(mCRC):The CRYSTAL trial(abstract)[J].J Clin Oncol,2007,25:164s.
  • 5Bokemeyer C,Bondarenko I,Hartmann JT,et al.K-RAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer with FOLFOX with or without Cetuximab:The OPUS experience (abstract)[J].J Clin Oncol,2008,26:178s.
  • 6van Cutsem E,Kǒhne CH,Hitre E,et al.Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer[J].N Engl J Med,2009,360(14):1408-1417.

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