离子通道噪声对神经元新陈代谢能量的影响

Effects of channel noise on metabolic energy cost of action potentials

利用随机Hodgkin-Huxley模型对发生在不同膜面积、不同温度下的神经元新陈代谢能量损耗进行了数值模拟研究.与实际神经元进行比较,表明神经元细胞膜存在一个最佳的膜面积和最佳的温度.在最佳的膜面积和温度下,神经元的新陈代谢能量损耗最小.最佳的膜面积与实际神经元膜面积一致,并且这个最佳的温度与室温一致.

We study the metabolic energy cost of action potential in neuron for various membrane sizes and at different temperatures. Using the occupation number method to model stochastic Hodgkin-Huxley neuron, we found that there exists a minimal metabolic energy cost near the real size of the membrane at room temperature.