美敏伪麻溶液治疗感染后咳嗽临床疗效观察

Clinical effect of dextromethorphan-chlorpheniramine-pseudoephedrine solution on postinfectious cough

目的:观察美敏伪麻溶液治疗感染后咳嗽的疗效。方法:78例感染后咳嗽的患者随机分为治疗组和对照组,对照组口服酮替芬片(1mg,bid,7d),阿奇霉素片(0.5g,qd,3d);治疗组口服美敏伪麻溶液(10mL,tid,7d),阿奇霉素片(0.5g,qd,3d);按咳嗽症状得分在7d后评价疗效。结果:治疗组与对照组治疗前咳嗽症状得分分别为(5.4±1.2)分及(5.5±1.2)分,2组间差异无显著性(P>0.05),治疗后得分分别为(2.3±1.3)分及(3.2±1.3)分,与治疗前相比,差异均有显著性(P均<0.01),治疗后治疗组症状得分低于对照组,2组间相比,差异有极显著性(P<0.01)。2组症状缓解率,治疗组治疗有效率为76.3%,对照组为45%,2组差异有极显著性(P<0.01),治疗组疗效优于对照组。结论:美敏伪麻溶液对感染后咳嗽患者的治疗有比较明显的疗效,可作为感染后咳嗽治疗的一种选择。

OBJECTIVE To observe the clinical effect of dextromethorphan-chlorpheniramine-pseudoephedrine solution on postinfectious cough. METHODS 78 patients with postinfectious cough were randomly divided into study group and control group. The control group was treated with ketotifen talblets 1 mg bid for 7 days and azithromycin tablets （Zithromax, Pfizer Pharmaceuticals Co. , Ltd） 0. 5 g qd for 3 days, the study group was treated with dextromethorphan-chlorpheniramine- pseudo- ephedrine solution （Robitussin,Wyeth Pharmaceutical Co. , Ltd） 10mL tid for 7 days and azithromycin Tablets. 0. 5 g qd for 3 days, Effects were evaluated after 7-day＇s treatment according to cough symptom score. RESULTS Before treatment, cough symptom scores of the study group and control group were 5. 4 ± 1.2 and 5. 5± 1.2 respectively, there was no significant difference between two groups （P〉0. 05）. After 7-day＇s treatment, the cough symptom scores of the study group and control group were 2. 3 ± 1.3 and 3. 2 ± 1.3 respectively, there were significant differences between before and after treatment for both groups （P〈0. 01 ）. After treatment, symptom scores of the study group were lower than that of control group, there were significant differences between two groups （P〈0.01 ）. The efficiency rate were 76. 3% in study group and 45% in control group, there were significant differences between two groups （P〈0. 01 ）. The clinical effects of study group was better than the control group. CONCLUSION Dextromethorphan chlorpheniramine-pseudoephedrine solution has significant therapeutic effects on postinfeetious cough,and can be a choose for the treatment of postinfectious cough.