老年心力衰竭患者核因子-κB与心功能的关系

Correlation between nuclear factor-kappa B and cardiac function in aged patients with congestive heart failure

目的:探讨老年心力衰竭(CHF)患者核因子-κB(NF-κB)与心功能的关系。方法:对46例老年CHF患者进行超声心动图检测和NF-κB检测,进行不同类型CHF、不同病因心功能与NF-κB水平变化的相关分析。结果:心功能Ⅱ级、Ⅲ级、Ⅳ级的左室射血分数(LVEF)、左室短轴缩短率(LVFS)和NF-κB的活化率均较心功能正常对照组明显增高(P<0.01或P<0.05);各级心功间差异均有显著性(P<0.05);随着心功能的恶化,NF-κB的活化率呈上升趋势;随NF-κB的活化率的增加,LVEF、LVFS均显著下降,呈显著的负相关(r值分别为-0.57和-0.65,P<0.05)。缺血性心脏病、高血压性心脏病和心瓣膜病及其他患者的心功能与正常对照组比较,均有非常显著的降低(P<0.01);不同病因患者的NF-κB活化率均较正常对照组显著增高(P<0.01),但不同病因间的心功能和NF-κB活化率差异无显著性(P>0.05)。结论:NF-κB活化率可评估心力衰竭的严重程度。

Objective To analyze the correlation between nuclear factor-kappa B （NF-κB） and cardiac function in aged patients with congestive heart failure （CHF）. Methods 46 patients received echocardiogram （ECG）, NF-κB levels were detected and its relationship with cardiac function was analyzed. Results Left ventricular ejection fraction （LVEF）, left ventricular fractional shortening （LVFS）, and NF-κB activation rate in patient with Ⅱ , Ⅲ, Ⅳ grade cardiac function, among whom there were significant differences （P 〈 0.05）, were significantly higher than those in normal controls （P 〈 0.01 or P 〈 0.05）. There were significant correlations between NF-κB activation rate and LVEF or LVFS （r = -0.57 and r = -0.65, P 〈 0.05）. Cardiac function was decreased （P 〈 0.01 ）, while NF-κB activation rate was increased （P 〈 0.01 ） in patients with ischemic heart disease, hepertensive cardiopaphy, or heart valve disorders, among whom there were no significant differences （P 〉 0.05）, as compared with those in normal controls. Conclusion Activation rate of NF-κB can be used to evaluate the severity of CHF in aged people.